IUBMB Enzyme Nomenclature


Accepted name: 9,13-epoxylabd-14-ene synthase

Reaction: peregrinol diphosphate = (13R)-9,13-epoxylabd-14-ene + diphosphate

For diagram of reaction click here

Glossary: peregrinol diphosphate = (13E)-9-hydroxy-8α-labd-13-en-15-yl diphosphate

Other name(s): ELS (gene name); TPS2 (gene name) (ambiguous); peregrinol-diphosphate diphosphate-lyase (9,13-epoxylabd-14-ene-forming)

Systematic name: peregrinol-diphosphate diphosphate-lyase [(13R)-9,13-epoxylabd-14-ene-forming]

Comments: Isolated from the plants Marrubium vulgare (white horehound) and Vitex agnus-castus (chaste tree). Involved in marrubiin biosynthesis.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Zerbe, P., Chiang, A., Dullat, H., O'Neil-Johnson, M., Starks, C., Hamberger, B. and Bohlmann, J. Diterpene synthases of the biosynthetic system of medicinally active diterpenoids in Marrubium vulgare. Plant J. 79 (2014) 914-927. [PMID: 24990389]

2. Heskes, A.M., Sundram, T.CM., Boughton, B.A., Jensen, N.B., Hansen, N.L., Crocoll, C., Cozzi, F., Rasmussen, S., Hamberger, B., Hamberger, B., Staerk, D., Møller, B.L. and Pateraki, I. Biosynthesis of bioactive diterpenoids in the medicinal plant Vitex agnus-castus. Plant J. 93 (2018) 943-958. [PMID: 29315936]

[EC created 2017]

Return to EC 4.2.3 home page
Return to EC 4.2 home page
Return to EC 4 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page