IUBMB Enzyme Nomenclature


Accepted name: ent-kaurene synthase

Reaction: ent-copalyl diphosphate = ent-kaurene + diphosphate

For diagram of reaction, click here and mechanism here.

Other name(s): ent-kaurene synthase B; ent-kaurene synthetase B; ent-copalyl-diphosphate diphosphate-lyase (cyclizing)

Systematic name: ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-kaurene-forming)

Comments: Part of a bifunctional enzyme involved in the biosynthesis of ent-kaurene. See also EC (ent-copalyl diphosphate synthase)

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9055-64-5


1. Fall, R.R., West, C.A. Purification and properties of kaurene synthetase from Fusarium moniliforme. J. Biol. Chem. 246 (1971) 6913-6928. [PMID: 4331199]

2. Yamaguchi, S., Saito, T., Abe, H., Yamane, H., Murofushi, N. and Kamiya, Y. Molecular cloning and characterization of a cDNA encoding the gibberellin biosynthetic enzyme ent-kaurene synthase B from pumpkin (Cucurbita maxima L.). Plant J. 10 (1996) 203-213. [PMID: 8771778]

3. Kawaide, H., Imai, R., Sassa, T. and Kamiya, Y. Ent-kaurene synthase from the fungus Phaeosphaeria sp. L487. cDNA isolation, characterization, and bacterial expression of a bifunctional diterpene cyclase in fungal gibberellin biosynthesis. J. Biol. Chem. 272 (1997) 21706-21712. [PMID: 9268298]

4. Toyomasu, T., Kawaide, H., Ishizaki, A., Shinoda, S., Otsuka, M., Mitsuhashi, W. and Sassa, T. Cloning of a full-length cDNA encoding ent-kaurene synthase from Gibberella fujikuroi: functional analysis of a bifunctional diterpene cyclase. Biosci. Biotechnol. Biochem. 64 (2000) 660-664. [PMID: 10803977]

[EC created 2002]

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