IUBMB Enzyme Nomenclature


Accepted name: valerianol synthase

Reaction: (2E,6E)-farnesyl diphosphate + H2O = valerianol + diphosphate

For diagram of reaction, click here

Glossary: valerianol = 2-[(2R,8R,8aS)-8,8a-dimethyl-1,2,3,4,6,7,8,8a-octahydronaphthalen-2-yl]propan-2-ol

Other name(s): ChTPS1 (gene name); CsiTPS8 (gene name)

Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (valerianol-forming)

Comments: The enzyme was characterized from the trees Camellia hiemalis and Camellia sinensis (black tea). The enzyme from Camellia hiemalis produces (2Z,6E)-hedycaryol as a minor product.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Hattan, J.I., Shindo, K., Sasaki, T., Ohno, F., Tokuda, H., Ishikawa, K. and Misawa, N. Identification of novel sesquiterpene synthase genes that mediate the biosynthesis of valerianol, which was an unknown ingredient of tea. Sci Rep 8 (2018) 12474. [PMID: 30127518]

[EC created 2019]

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