IUBMB Enzyme Nomenclature


Accepted name: (–)-cyatha-3,12-diene synthase

Reaction: geranylgeranyl diphosphate = (–)-cyatha-3,12-diene + diphosphate

Diagram of reaction click here

Glossary: (–)-cyatha-3,12-diene = (3aS,5aS,10aS)-3a,5a,8-trimethyl-1-(propan-2-yl)-2,3,4,5,6,9,10,10a-octahydrocyclohepta[e]indene

Other name(s): eriG (gene name); CyaTC

Systematic name: geranylgeranyl diphosphate-lyase [(–)-cyatha-3,12-diene-forming]

Comments: The enzyme, characterized from the fungi Hericium erinaceus and Cyathus africanus, requires Mg2+ for activity.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Yang, Y.L., Zhang, S., Ma, K., Xu, Y., Tao, Q., Chen, Y., Chen, J., Guo, S., Ren, J., Wang, W., Tao, Y., Yin, W.B. and Liu, H. Discovery and characterization of a new family of diterpene cyclases in bacteria and fungi. Angew. Chem. Int. Ed. Engl. 56 (2017) 4749-4752. [PMID: 28371074]

[EC created 2022]

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