Reaction: geranylgeranyl diphosphate + H2O = neoverrucosan-5β-ol + diphosphate
Diagram of reaction click here
Glossary: neoverrucosan-5β-ol = (1aS,3R,3aS,5aR,8bR,8cS,12S,14S)-1a,3a,5a-trimethyl-8-(propan-2-yl)tetradecahydrocyclopenta[a]cyclopropa[h]naphthalen-3-ol
Other name(s): SapTC1
Systematic name: geranylgeranyl- diphosphate diphosphate-lyase (neoverrucosan-5β-ol-forming)
Comments: Requires Mg2+. Characterized from the marine bacterium Saprospira grandis.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Yang, Y.L., Zhang, S., Ma, K., Xu, Y., Tao, Q., Chen, Y., Chen, J., Guo, S., Ren, J., Wang, W., Tao, Y., Yin, W.B. and Liu, H. Discovery and characterization of a new family of diterpene cyclases in bacteria and fungi. Angew. Chem. Int. Ed. Engl. 56 (2017) 4749-4752. [PMID: 28371074]