IUBMB Enzyme Nomenclature


Accepted name: lydicene synthase

Reaction: geranylgeranyl diphosphate = lydicene + diphosphate

Diagram of reaction click here

Glossary: lydicene = (4aR,6aS)-2,2,4α,6α,9-pentamethyl-2,3,4,5,6,7,10,11-octahydro-1Hcyclohepta[a]naphthalene

Other name(s): StlTC

Systematic name: geranylgerany-diphosphate diphosphate-lyase (lydicene-forming)

Comments: Requires Mg2+. Characterized from the bacterium Streptomyces lydicus.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Yang, Y.L., Zhang, S., Ma, K., Xu, Y., Tao, Q., Chen, Y., Chen, J., Guo, S., Ren, J., Wang, W., Tao, Y., Yin, W.B. and Liu, H. Discovery and characterization of a new family of diterpene cyclases in bacteria and fungi. Angew. Chem. Int. Ed. Engl. 56 (2017) 4749-4752. [PMID: 28371074]

[EC created 2022]

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