IUBMB Enzyme Nomenclature


Accepted name: (+)-exo-β-bergamotene synthase

Reaction: (2E,6E)-farnesyl diphosphate = (+)-exo-β-bergamotene + diphosphate

Diagram of reaction click here and mechanism click here

Glossary: (+)-exo-β-bergamotene = β-trans-bergamotene = (1S,5S,6R)-6-methyl-2-methylidene-6-(4-methylpent-3-enyl)bicyclo[3.1.1]heptane
fumagillin = w(2E,4E,6E,8E)-10-({(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]oct-6-yl}oxy)-10-oxodeca-2,4,6,8-tetraenoate

Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-exo-β-bergamotene-forming]

Comments: The enzyme, characterized from the mold Aspergillus fumigatus, participates in the biosynthesis of the meroterpenoid fumagillin.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Lin, H.C., Chooi, Y.H., Dhingra, S., Xu, W., Calvo, A.M. and Tang, Y. The fumagillin biosynthetic gene cluster in Aspergillus fumigatus encodes a cryptic terpene cyclase involved in the formation of β-trans-bergamotene. J. Am. Chem. Soc. 135 (2013) 4616-4619. [PMID: 23488861]

[EC created 2022]

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