Reaction: (2E,6E)-farnesyl diphosphate + H2O = (+)-δ-cadinol + diphosphate
For diagram of reaction click here
Glossary: (+)-δ-cadinol = (1S,4R,4aS,8aR)-1,6-dimethyl-4-(propan-2-yl)-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-ol = (+)-torreyol
Other name(s): δ-cadinol synthase (ambiguous)
Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-δ-cadinol-forming]
Comments: The enzyme is involved in the biosynthesis of sesquiterpenoids from (2E,6E)-farnesyl diphosphate in fungi such as Boreostereum vibrans and Coniophora puteana
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Zhou, H., Yang, Y.L., Zeng, J., Zhang, L., Ding, Z.H. and Zeng, Y. Identification and characterization of a δ-cadinol synthase potentially involved in the formation of boreovibrins in Boreostereum vibrans of basidiomycota. Nat. Prod. Bioprospect. 6 (2016) 167-171. [PMID: 27038475]
2. Ringel, M., Dimos, N., Himpich, S., Haack, M., Huber, C., Eisenreich, W., Schenk, G., Loll, B. and Bruck, T. Biotechnological potential and initial characterization of two novel sesquiterpene synthases from Basidiomycota Coniophora puteana for heterologous production of δ-cadinol. Microb. Cell Fact. 21 (2022) 64. [PMID: 35440053]