Reaction: geranylgeranyl diphosphate = variediene + diphosphate
For diagram of reaction and mechanism click here
Glossary: variediene = (3aR,3bS,6E,10Z,11aR)-3,3,6,10,11a-pentamethyl-2,3,3a,3b,4,5,8,9,11,11a-decahydro-1H-cyclonona[a]pentalene
Other name(s): EvVS
Systematic name: geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, variediene-forming)
Comments: A diterpenoid synthase enzyme isolated from the fungus Aspergillus stellatus.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Qin, B., Matsuda, Y., Mori, T., Okada, M., Quan, Z., Mitsuhashi, T., Wakimoto, T. and Abe, I. An unusual chimeric diterpene synthase from Emericella variecolor and its functional conversion into a sesterterpene synthase by domain swapping. Angew. Chem. Int. Ed. Engl. 55 (2016) 1658-1661. [PMID: 26546087]