Reaction: geranylgeranyl diphosphate = cattleyene + diphosphate
For diagram of reaction click here and mechanism click here
Glossary: cattleyene = (3R,3aS,5aS,5bR,8aR)-3,3a,6,6,8a-pentamethyl-2,3,3a,4,5,5a,5b,6,7,8,8a,9-dodecahydro-1H-pentaleno[2,1-e]indene
Other name(s): CyS
Systematic name: geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, cattleyene-formimg)
Comments: A diterpene synthase isolated from the bacterium Streptantibioticus cattleyicolor.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Rinkel, J., Steiner, S.T. and Dickschat, J.S. Diterpene biosynthesis in actinomycetes: studies on cattleyene synthase and phomopsene synthase. Angew. Chem. Int. Ed. Engl. 58 (2019) 9230-9233. [PMID: 31034729]
2. Xing, B., Xu, H., Li, A., Lou, T., Xu, M., Wang, K., Xu, Z., Dickschat, J.S., Yang, D. and Ma, M. Crystal structure based mutagenesis of cattleyene synthase leads to the generation of rearranged polycyclic diterpenes. Angew. Chem. Int. Ed. Engl. 61 (2022) e202209785. [PMID: 35819825]