Reaction: D-mannose 6-phosphate = 2-deoxy-4-epi-scyllo-inosose + phosphate
Glossary: 2-deoxy-4-epi-scyllo-inosose = (2R,3S,4S,5S)-2,3,4,5-tetrahydroxycyclohexan-1-one
Other name(s): eboD (gene name)
Systematic name: D-mannose-6-phosphate phosphate-lyase (2-deoxy-4-epi-scyllo-inosose-forming)
Comments: Requires Co2+ or Ni2+. The enzyme has been characterized from the cyanobacterium Nostoc punctiforme and the Gram-negative cellulose degrading bacterium Sporocytophaga myxococcoides. cf. EC 4.2.3.124, 2-deoxy-scyllo-inosose synthase
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Tanoeyadi, S., Zhou, W., Osborn, A.R., Tsunoda, T., Samadi, A., Burade, S., Waldo, T.J., Higgins, M.A. and Mahmud, T. 2-Deoxy-4-epi-scyllo-inosose (DEI) is the product of EboD, a highly conserved dehydroquinate synthase-like enzyme in bacteria and eustigmatophyte algae. ACS Chem. Biol. 19 (2024) 2277-2283. [PMID: 39404639]