Reaction: (2E,6E)-farnesyl diphosphate = (Z)-γ-bisabolene + diphosphate
For diagram of reaction click here and mechanism click here.
Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(Z)-γ-bisabolene-forming]
Comments: This sesquiterpenoid enzyme is constitutively expressed in the root, hydathodes and stigma of the plant Arabidopsis thaliana. If the leaves of the plant are wounded, e.g. by cutting, the enzyme is also induced close to the wound site. The sesquiterpenoids (E)-nerolidol and α-bisabolol are also produced by this enzyme as minor products.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Ro, D.K., Ehlting, J., Keeling, C.I., Lin, R., Mattheus, N. and Bohlmann, J. Microarray expression profiling and functional characterization of AtTPS genes: duplicated Arabidopsis thaliana sesquiterpene synthase genes At4g13280 and At4g13300 encode root-specific and wound-inducible (Z)-γ-bisabolene synthases. Arch. Biochem. Biophys. 448 (2006) 104-116. [PMID: 16297850]