IUBMB Enzyme Nomenclature

EC 4.2.3.41

Accepted name: elisabethatriene synthase

Reaction: geranylgeranyl diphosphate = elisabethatriene + diphosphate

For reaction pathway click here and mechanism click here.

Other name(s): elisabethatriene cyclase

Systematic name: geranylgeranyl-diphosphate diphosphate-lyase (elisabethatriene-forming)

Comments: Requires Mg2+ or less efficiently Mn2+. The enzyme is also able to use farnesyl diphosphate and geranyl diphosphate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 334022-59-2

References:

1. Kohl, A.C. and Kerr, R.G. Identification and characterization of the pseudopterosin diterpene cyclase, elisabethatriene synthase, from the marine gorgonian, Pseudopterogorgia elisabethae. Arch. Biochem. Biophys. 424 (2004) 97-104. [PMID: 15019841]

2. Bruck, T.B. and Kerr, R.G. Purification and kinetic properties of elisabethatriene synthase from the coral Pseudopterogorgia elisabethae. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 143 (2006) 269-278. [PMID: 16423548]

[EC 4.2.3.41 created 2009]


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