IUBMB Enzyme Nomenclature


Accepted name: (+)-α-santalene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]

Reaction: (2Z,6Z)-farnesyl diphosphate = (+)-α-santalene + diphosphate

For diagram of reaction click here.

Other name(s): SBS

Systematic name: (2Z,6Z)-farnesyl-diphosphate lyase (cyclizing; (+)-α-santalene-forming)

Comments: The enzyme synthesizes a mixture of sesquiterpenoids from (2Z,6Z)-farnesyl diphosphate. Following dephosphorylation of (2Z,6Z)-farnesyl diphosphate, the (2Z,6Z)-farnesyl carbocation is converted to either the (6R)- or the (6S)-bisabolyl cations depending on the stereochemistry of the 6,1 closure. The (6R)-bisabolyl cation will then lead to the formation of (+)-α-santalene, while the (6S)-bisabolyl cation will give rise to (–)-endo-α-bergamotene (see EC and (+)-endo-β-bergamotene (see EC Small amounts of (–)-epi-β-santalene are also formed from the (6R)-bisabolyl cation and small amounts of (–)-exo-α-bergamotene are formed from the (6S)-bisabolyl cation [1].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Sallaud, C., Rontein, D., Onillon, S., Jabes, F., Duffe, P., Giacalone, C., Thoraval, S., Escoffier, C., Herbette, G., Leonhardt, N., Causse, M. and Tissier, A. A novel pathway for sesquiterpene biosynthesis from Z,Z-farnesyl pyrophosphate in the wild tomato Solanum habrochaites. Plant Cell 21 (2009) 301-317. [PMID: 19155349]

[EC created 2010]

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