IUBMB Enzyme Nomenclature


Accepted name: trichodiene synthase

Reaction: (2E,6E)-farnesyl diphosphate = trichodiene + diphosphate

For reaction pathway click here.

Other name(s): trichodiene synthetase; sesquiterpene cyclase; trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase; trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming)

Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming)

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 101915-76-8


1. Hohn, T.M. and Vanmiddlesworth, F. Purification and characterization of the sesquiterpene cyclase trichodiene synthetase from Fusarium sporotrichioides. Arch. Biochem. Biophys. 251 (1986) 756-761. [PMID: 3800398]

2. Hohn, T.M. and Beremand, P.D. Isolation and nucleotide sequence of a sesquiterpene cyclase gene from the trichothecene-producing fungus Fusarium sporotrichioides. Gene 79 (1989) 131-138. [PMID: 2777086]

3. Rynkiewicz, M.J., Cane, D.E. and Christianson, D.W. Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade. Proc. Natl. Acad. Sci. USA 98 (2001) 13543-13548. [PMID: 11698643]

[EC created 1989 as EC, transferred 2000 to EC]

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