Reaction: (2E,6E)-farnesyl diphosphate + H2O = β-eudesmol + diphosphate
For diagram of rection click here and for mechanism click here
Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (β-eudesmol-forming)
Comments: The recombinant enzyme from ginger (Zingiber zerumbet) gives 62.6% β-eudesmol, 16.8% 10-epi-γ-eudesmol (cf. EC 126.96.36.199, 10-epi-γ-eudesmol synthase), 10% α-eudesmol (cf. EC 188.8.131.52, α-eudesmol synthase), and 5.6% aristolene.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Yu, F., Harada, H., Yamasaki, K., Okamoto, S., Hirase, S., Tanaka, Y., Misawa, N. and Utsumi, R. Isolation and functional characterization of a β-eudesmol synthase, a new sesquiterpene synthase from Zingiber zerumbet Smith. FEBS Lett. 582 (2008) 565-572. [PMID: 18242187]