IUBMB Enzyme Nomenclature


Accepted name: patchoulol synthase

Reaction: (2E,6E)-farnesyl diphosphate + H2O = patchoulol + diphosphate

For diagram of reaction click here and mechanism click here.

Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (patchoulol-forming)

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Croteau, R., Munck, S.L., Akoh, C.C., Fisk, H.J. and Satterwhite, D.M. Biosynthesis of the sesquiterpene patchoulol from farnesyl pyrophosphate in leaf extracts of Pogostemon cablin (patchouli): mechanistic considerations. Arch. Biochem. Biophys. 256 (1987) 56-68. [PMID: 3038029]

2. Munck, S.L. and Croteau, R. Purification and characterization of the sesquiterpene cyclase patchoulol synthase from Pogostemon cablin. Arch. Biochem. Biophys. 282 (1990) 58-64. [PMID: 2171435]

3. Faraldos, J.A., Wu, S., Chappell, J. and Coates, R.M. Doubly deuterium-labeled patchouli alcohol from cyclization of singly labeled [2-2H1]farnesyl diphosphate catalyzed by recombinant patchoulol synthase. J. Am. Chem. Soc. 132 (2010) 2998-3008. [PMID: 20148554]

[EC created 2011]

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