Reaction: (2E,6E)-farnesyl diphosphate = (–)-α-gurjunene + diphosphate
For diagram of reaction click here.
Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(–)-α-gurjunene-forming]
Comments: Initial cyclization probably gives biyclogermacrene in an enzyme bound form which is not released to the medium. The enzyme from Solidago canadensis also forms a small amount of (+)-γ-gurjunene [1].
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
References:
1. Schmidt, C.O., Bouwmeester, H.J., Bulow, N. and Konig, W.A. Isolation, characterization, and mechanistic studies of (–)-α-gurjunene synthase from Solidago canadensis. Arch. Biochem. Biophys. 364 (1999) 167-177. [PMID: 10190971]