Reaction: (2E,6E)-farnesyl diphosphate = (+)-valencene + diphosphate
For diagram of reaction click here.
Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (valencene-forming)
Comments: The recombinant enzyme from Vitis vinifera gave 49.5% (+)-valencene and 35.5% (–)-7-epi-α-selinene. Initial cyclization gives (+)-germacrene A in an enzyme bound form which is not released to the medium.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
References:
1. Lucker, J., Bowen, P. and Bohlmann, J. Vitis vinifera terpenoid cyclases: functional identification of two sesquiterpene synthase cDNAs encoding (+)-valencene synthase and (–)-germacrene D synthase and expression of mono- and sesquiterpene synthases in grapevine flowers and berries. Phytochemistry 65 (2004) 2649-2659. [PMID: 15464152]