Reaction: geranylgeranyl diphosphate = casbene + diphosphate
For reaction pathway click here.
Other name(s): casbene synthetase; geranylgeranyl-diphosphate diphosphate-lyase (cyclizing)
Systematic name: geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, CASbene-forming)
Comments: The enzyme from castor bean (Ricinus communis) produces the antifungal diterpene casbene.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 69106-45-2
References:
1. Moesta, P. and West, C.A. Casbene synthetase: regulation of phytoalexin biosynthesis in Ricinus communis L. seedlings. Purification of casbene synthetase and regulation of its biosynthesis during elicitation. Arch. Biochem. Biophys. 238 (1985) 325-333. [PMID: 3985625]
2. Mau, C.J. and West, C.A. Cloning of casbene synthase cDNA: evidence for conserved structural features among terpenoid cyclases in plants. Proc. Natl. Acad. Sci. USA 91 (1994) 8497-8501. [PMID: 8078910]