IUBMB Enzyme Nomenclature


Accepted name: exo-α-bergamotene synthase

Reaction: (2E,6E)-farnesyl diphosphate = (–)-exo-α-bergamotene + diphosphate

For diagram of reaction click here and mechanism click here.

Glossary: (–)-exo-α-bergamotene = (–)-trans-α-bergamotene = (1S,5S,6R)-2,6-dimethyl-6-(4-methylpent-3-en-1-yl)bicyclo[3.1.1]hept-2-ene

Other name(s): trans-α-bergamotene synthase; LaBERS (gene name)

Systematic name: (2E,6E)-farnesyl-diphosphate lyase (cyclizing, (–)-exo-α-bergamotene-forming)

Comments: The enzyme synthesizes a mixture of sesquiterpenoids from (2E,6E)-farnesyl diphosphate. As well as (–)-exo-α-bergamotene (74%) there were (E)-nerolidol (10%), (Z)-α-bisabolene (6%), (E)-β-farnesene (5%) and β-sesquiphellandrene (1%).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Schnee, C., Kollner, T.G., Held, M., Turlings, T.C., Gershenzon, J. and Degenhardt, J. The products of a single maize sesquiterpene synthase form a volatile defense signal that attracts natural enemies of maize herbivores. Proc. Natl. Acad. Sci. USA 103 (2006) 1129-1134. [PMID: 16418295]

2. Landmann, C., Fink, B., Festner, M., Dregus, M., Engel, K.H. and Schwab, W. Cloning and functional characterization of three terpene synthases from lavender (Lavandula angustifolia). Arch. Biochem. Biophys. 465 (2007) 417-429. [PMID: 17662687]

[EC created 2011]

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