IUBMB Enzyme Nomenclature


Accepted name: (–)-α-cuprenene synthase

Reaction: (2E,6E)-farnesyl diphosphate = (–)-α-cuprenene + diphosphate

For diagram of reaction click here.

Other name(s): Cop6

Systematic name: (–)-α-cuprenene hydrolase [cyclizing, (–)-α-cuprenene-forming]

Comments: The enzyme from the fungus Coprinopsis cinerea produces (–)-α-cuprenene with high selectivity.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Lopez-Gallego, F., Agger, S.A., Abate-Pella, D., Distefano, M.D. and Schmidt-Dannert, C. Sesquiterpene synthases Cop4 and Cop6 from Coprinus cinereus: catalytic promiscuity and cyclization of farnesyl pyrophosphate geometric isomers. Chembiochem. 11 (2010) 1093-1106. [PMID: 20419721]

[EC created 2012]

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