IUBMB Enzyme Nomenclature


Accepted name: (–)-δ-cadinene synthase

Reaction: (2E,6E)-farnesyl diphosphate = (–)-δ-cadinene + diphosphate

For diagram of reaction click here.

Glossary: (–)-δ-cadinene = (1R,8aS)-4,7-dimethyl-1-(propan-2-yl)-1,2,3,5,6,8a-hexahydronaphthalene

Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (–)-δ-cadinene-forming)

Comments: The cyclization mechanism involves an intermediate nerolidyl diphosphate leading to a helminthogermacradienyl cation. Following a 1,3-hydride shift of the original 1-pro-S hydrogen of (2E,6E)-farnesyl diphosphate, cyclization and deprotonation gives (–)-δ-cadinene.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Hu, Y., Chou, W.K., Hopson, R. and Cane, D.E. Genome mining in Streptomyces clavuligerus: expression and biochemical characterization of two new cryptic sesquiterpene synthases. Chem. Biol. 18 (2011) 32-37. [PMID: 21276937]

[EC created 2012]

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