Reaction: salutaridinol 7-O-acetate = thebaine + acetate
For diagram of reaction click here
Other name(s): THS
Systematic name: salutaridinol 7-O-acetate acetate-lyase (thebaine forming)
Comments: Isolated from the plant Papaver somniferum (opium poppy). The reaction occurs spontaneously when the pH is between 8-9, but the enzyme is required at the physiological pH, which is close to 7.
Links to other databases: BRENDA, EXPASY, ExplorEnz, KEGG, MetaCyc, PDB, CAS registry number:
1. Chen, X., Hagel, J.M., Chang, L., Tucker, J.E., Shiigi, S.A., Yelpaala, Y., Chen, H.Y., Estrada, R., Colbeck, J., Enquist-Newman, M., Ibanez, A.B., Cottarel, G., Vidanes, G.M. and Facchini, P.J. A pathogenesis-related 10 protein catalyzes the final step in thebaine biosynthesis. Nat. Chem. Biol. 14 (2018) 738-743. [PMID: 29807982]