Reaction: (1R)-(2-amino-1-hydroxyethyl)phosphonate = phosphonoacetaldehyde + NH3 (overall reaction)
(1a) (1R)-(2-amino-1-hydroxyethyl)phosphonate = (E)-2-aminoethenylphosphonate + H2O
(1b) (E)-2-aminoethenylphosphonate + H2O = phosphonoacetaldehyde + NH3
Glossary: phosphonoacetaldehyde = (2-oxoethyl)phosphonate
Other name(s): pbfA (gene name)
Systematic name: (1R)-(2-amino-1-hydroxyethyl)phosphonate ammonia-lyase
Comments: A pyridoxal-phosphate enzyme. This bacterial enzyme, characterized from the marine bacterium Vibrio splendidus, expands the substrate scope of a widespread pathway for the degradation of 2-aminoethylphosphonate. The enzyme is highly specific and does not act on the S enantiomer of 1-hydroxy-2-aminoethylphosphonate or other structurally related compounds.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Zangelmi, E., Stankovic, T., Malatesta, M., Acquotti, D., Pallitsch, K. and Peracchi, A. Discovery of a new, recurrent enzyme in bacterial phosphonate degradation: (R)-1-hydroxy-2-aminoethylphosphonate ammonia-lyase. Biochemistry 60 (2021) 1214-1225. [PMID: 33830741]