IUBMB Enzyme Nomenclature


Accepted name: nitrosuccinate lyase

Reaction: 2-nitrobutanedioate = fumarate + nitrite

Glossary: 2-nitrobutanedioate = nitrosuccinate

Other name(s): creD (gene name)

Systematic name: 2-nitrobutanedioate lyase (fumarate-forming)

Comments: The enzyme, found in some Actinobacteria, is involved in a pathway that forms nitrite, which is subsequently used to generate a diazo group in some secondary metabolites.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Sugai, Y., Katsuyama, Y. and Ohnishi, Y. A nitrous acid biosynthetic pathway for diazo group formation in bacteria. Nat. Chem. Biol. 12 (2016) 73-75. [PMID: 26689788]

2. Hagihara, R., Katsuyama, Y., Sugai, Y., Onaka, H. and Ohnishi, Y. Novel desferrioxamine derivatives synthesized using the secondary metabolism-specific nitrous acid biosynthetic pathway in Streptomyces davawensis, J. Antibiot. (Tokyo) 71 (2018) 911-919. [PMID: 30120394]

[EC created 2021]

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