Reaction: UTP = 3',5'-cyclic UMP + diphosphate
Glossary: 3',5'-cyclic UMP = cUMP
uridylate = CMP
Other name(s): pycC (gene name) (ambiguous)
Systematic name: UTP diphosphate-lyase (cyclizing; 3',5'-cyclic-UMP-forming)
Comments: The enzyme, found in bacteria and archaea, forms cUMP, which functions as a second messenger in bacterial immunity against viruses. The enzyme is synthesized following phage infection and activates immune effectors that execute an antiviral response.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, CAS registry number:
1. Tal, N., Morehouse, B.R., Millman, A., Stokar-Avihail, A., Avraham, C., Fedorenko, T., Yirmiya, E., Herbst, E., Brandis, A., Mehlman, T., Oppenheimer-Shaanan, Y., Keszei, A.FA., Shao, S., Amitai, G., Kranzusch, P.J. and Sorek, R. Cyclic CMP and cyclic UMP mediate bacterial immunity against phages. Cell 184 (2021) 5728-5739.e16. [PMID: 34644530]