IUBMB Enzyme Nomenclature


Accepted name: sirohydrochlorin nickelchelatase

Reaction: Ni-sirohydrochlorin + 2 H+ = sirohydrochlorin + Ni2+

For diagram of reaction click here.

Other name(s): cfbA (gene name)

Systematic name: Ni-sirohydrochlorin nickel-lyase (sirohydrochlorin-forming)

Comments: The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, participates in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC, coenzyme-B sulfoethylthiotransferase. It catalyses the insertion of the nickel ion into sirohydrochlorin.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number:


1. Zheng, K., Ngo, P.D., Owens, V.L., Yang, X.P. and Mansoorabadi, S.O. The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea. Science 354 (2016) 339-342. [PMID: 27846569]

[EC created 2017]

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