Reaction: Ni-sirohydrochlorin + 2 H+ = sirohydrochlorin + Ni2+
For diagram of reaction click here.
Other name(s): cfbA (gene name)
Systematic name: Ni-sirohydrochlorin nickel-lyase (sirohydrochlorin-forming)
Comments: The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, participates in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 188.8.131.52, coenzyme-B sulfoethylthiotransferase. It catalyses the insertion of the nickel ion into sirohydrochlorin.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number:
1. Zheng, K., Ngo, P.D., Owens, V.L., Yang, X.P. and Mansoorabadi, S.O. The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea. Science 354 (2016) 339-342. [PMID: 27846569]