IUBMB Enzyme Nomenclature


Accepted name: heme ligase

Reaction: 2 ferriprotoporphyrin IX = β-hematin

Other name(s): heme detoxification protein; HDP; hemozoin synthase

Systematic name: Fe3+:ferriprotoporphyrin IX ligase (β-hematin-forming)

Comments: This heme detoxifying enzyme is found in Plasmodium parasites and converts toxic heme to crystalline hemozoin. These organisms lack the mammalian heme oxygenase for elimination of heme.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Jani, D., Nagarkatti, R., Beatty, W., Angel, R., Slebodnick, C., Andersen, J., Kumar, S. and Rathore, D. HDP-a novel heme detoxification protein from the malaria parasite. PLoS Pathog. 4 (2008) e1000053. [PMID: 18437218]

[EC created 2009]

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