IUBMB Enzyme Nomenclature


Accepted name: L-Ala-D/L-Glu epimerase

Reaction: L-alanyl-D-glutamate = L-alanyl-L-glutamate

Other name(s): YkfB; YcjG; AEE; AE epimerase

Systematic name: L-alanyl-D-glutamate epimerase

Comments: The enzyme, characterized from the bacteria Escherichia coli and Bacillus subtilis, is involved in the recycling of the murein peptide, of which L-Ala-D-Glu is a component. In vitro the enzyme from Escherichia coli epimerizes several L-Ala-L-X dipeptides with broader specificity than the enzyme from Bacillus subtilis.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Schmidt, D.M., Hubbard, B.K. and Gerlt, J.A. Evolution of enzymatic activities in the enolase superfamily: functional assignment of unknown proteins in Bacillus subtilis and Escherichia coli as L-Ala-D/L-Glu epimerases. Biochemistry 40 (2001) 15707-15715. [PMID: 11747447]

2. Gulick, A.M., Schmidt, D.M., Gerlt, J.A. and Rayment, I. Evolution of enzymatic activities in the enolase superfamily: crystal structures of the L-Ala-D/L-Glu epimerases from Escherichia coli and Bacillus subtilis. Biochemistry 40 (2001) 15716-15724. [PMID: 11747448]

[EC created 2015]

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