IUBMB Enzyme Nomenclature


Accepted name: 4-hydroxyproline epimerase

Reaction: trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline

For reaction pathway click here.

Other name(s): hydroxyproline epimerase; hydroxyproline 2-epimerase; L-hydroxyproline epimerase

Systematic name: 4-hydroxyproline 2-epimerase

Comments: Also interconverts trans-4-hydroxy-D-proline and cis-4-hydroxy-L-proline.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9024-23-1


1. Adams, E. and Norton, I.L. Purification and properties of inducible hydroxyproline 2-epimerase from Pseudomonas. J. Biol. Chem. 239 (1964) 1525-1535.

[EC created 1965, modified 1983]

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