Reaction: (1S)-(2-amino-1-hydroxyethyl)phosphonate = (1R)-(2-amino-1-hydroxyethyl)phosphonate
Other name(s): 1-hydroxy-2-aminoethylphosphonate racemase; HAEP racemase; pbfF (gene name)
Systematic name: 2-amino-1-hydroxyethylphosphonate racemase
Comments: The enzyme, characterized from the bacterium Mesorhizobium plurifarium, contains an NAD+ cofactor that is reduced transiently during the reaction.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Ruffolo, F., Conciatori, S., Merici, G., Dinhof, T., Chin, J.P., Rivetti, C., Secchi, A., Pallitsch, K. and Peracchi, A. Genomic context analysis enables the discovery of an unusual NAD-dependent racemase in phosphonate catabolism. FEBS J. 292 (2025) 4272-4288. [PMID: 40384479]