IUBMB Enzyme Nomenclature


Accepted name: 2-epi-5-epi-valiolone epimerase

Reaction: 2-epi-5-epi-valiolone = 5-epi-valiolone

For diagram of reaction click here.

Glossary: 2-epi-5-epi-valiolone= (2S,3S,4S,5R)-2,3,4,5-tetrahydroxy-5-(hydroxymethyl)cyclohexanone
5-epi-valiolone = (2R,3S,4S,5R)-2,3,4,5-tetrahydroxy-5-(hydroxymethyl)cyclohexanone

Other name(s): CetB; EVE

Systematic name: 2-epi-5-epi-valiolone 2-epimerase

Comments: The enzyme, characterized from the bacterium Actinomyces sp. Lu 9419, is involved in the biosynthesis of the antitumor agent cetoniacytone A.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Wu, X., Flatt, P.M., Xu, H. and Mahmud, T. Biosynthetic gene cluster of cetoniacytone A, an unusual aminocyclitol from the endosymbiotic Bacterium Actinomyces sp. Lu 9419. Chembiochem 10 (2009) 304-314. [PMID: 19101977]

[EC created 2015]

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