IUBMB Enzyme Nomenclature

EC 5.1.3.36

Accepted name: heparosan-glucuronate 5-epimerase

Reaction: [heparosan]-D-glucuronate = [acharan]-L-iduronate

Glossary: acharan = [GlcNAc-α-(1→4)-IdoA-α-(1→4)]n
heparosan = [GlcNAc-α-(1→4)-GlcA-β-(1→4)]n

Other name(s): HG-5epi

Systematic name: [heparosan]-D-glucuronate 5-epimerase

Comments: The enzyme, characterized from the giant African snail Achatina fulica, participates in the biosynthetic pathway of acharan sulfate. Unlike EC 5.1.3.17, heparosan-N-sulfate-glucuronate 5-epimerase, it shows no activity with D-glucuronate residues in heparosan-N-sulfate.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:

References:

1. Mochizuki, H., Yamagishi, K., Suzuki, K., Kim, Y.S. and Kimata, K. Heparosan-glucuronate 5-epimerase: Molecular cloning and characterization of a novel enzyme. Glycobiology 25 (2015) 735-744. [PMID: 25677302]

[EC 5.1.3.36 created 2015]


Return to EC 5.1.3 home page
Return to EC 5.1 home page
Return to EC 5 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page