IUBMB Enzyme Nomenclature


Accepted name: heparosan-glucuronate 5-epimerase

Reaction: [heparosan]-D-glucuronate = [acharan]-L-iduronate

Glossary: acharan = [GlcNAc-α-(1→4)-IdoA-α-(1→4)]n
heparosan = [GlcNAc-α-(1→4)-GlcA-β-(1→4)]n

Other name(s): HG-5epi

Systematic name: [heparosan]-D-glucuronate 5-epimerase

Comments: The enzyme, characterized from the giant African snail Achatina fulica, participates in the biosynthetic pathway of acharan sulfate. Unlike EC, heparosan-N-sulfate-glucuronate 5-epimerase, it shows no activity with D-glucuronate residues in heparosan-N-sulfate.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Mochizuki, H., Yamagishi, K., Suzuki, K., Kim, Y.S. and Kimata, K. Heparosan-glucuronate 5-epimerase: Molecular cloning and characterization of a novel enzyme. Glycobiology 25 (2015) 735-744. [PMID: 25677302]

[EC created 2015]

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