IUBMB Enzyme Nomenclature


Accepted name: L-ribulose-5-phosphate 4-epimerase

Reaction: L-ribulose 5-phosphate = D-xylulose 5-phosphate

For diagram click here or click here.

Other name(s): phosphoribulose isomerase; ribulose phosphate 4-epimerase; L-ribulose-phosphate 4-epimerase; L-ribulose 5-phosphate 4-epimerase; AraD; L-Ru5P

Systematic name: L-ribulose-5-phosphate 4-epimerase

Comments: Requires a divalent cation for activity.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9024-19-5


1. Burma, D.P. and Horecker, B.L. IV. L-Ribulose-5-phosphate 4-epimerase. Pentose formation by Lactobacillus plantarum. J. Biol. Chem. 231 (1958) 1053-1064. [PMID: 13539036]

2. Deupree, J.D. and Wood, W.A. L-Ribulose 5-phosphate 4-epimerase of Aerobacter aerogenes. Evidence for nicotinamide adenine dinucleotide-independent 4-epimerization by the crystalline enzyme. J. Biol. Chem. 245 (1970) 3988-3995. [PMID: 4395381]

3. Lee, N., Patrick, J.W. and Masson, M. Crystalline L-ribulose 5-phosphate 4-epimerase from Escherichia coli. J. Biol. Chem. 243 (1968) 4700-4705. [PMID: 4879898]

4. Wolin, M.J., Simpson, F.J. and Wood, W.A. Degradation of L-arabinose by Aerobacter aerogenes. III. Identification and properties of L-ribulose-5-phosphate 4-epimerase. J. Biol. Chem. 232 (1958) 559-575. [PMID: 13549442]

5. Andersson, A., Schneider, G. and Lindqvist, Y. Purification and preliminary X-ray crystallographic studies of recombinant L-ribulose-5-phosphate 4-epimerase from Escherichia coli. Protein Sci. 4 (1995) 1648-1650. [PMID: 8520491]

6. Lee, L.V., Poyner, R.R., Vu, M.V. and Cleland, W.W. Role of metal ions in the reaction catalyzed by L-ribulose-5-phosphate 4-epimerase. Biochemistry 39 (2000) 4821-4830. [PMID: 10769139]

7. Samuel, J., Luo, Y., Morgan, P.M., Strynadka, N.C. and Tanner, M.E. Catalysis and binding in L-ribulose-5-phosphate 4-epimerase: a comparison with L-fuculose-1-phosphate aldolase. Biochemistry 40 (2001) 14772-14780. [PMID: 11732896]

[EC created 1965, modified 2005]

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