Reaction: N-acyl-D-glucosamine 6-phosphate = N-acyl-D-mannosamine 6-phosphate
Other name(s): acylglucosamine-6-phosphate 2-epimerase; acylglucosamine phosphate 2-epimerase
Systematic name: N-acyl-D-glucosamine-6-phosphate 2-epimerase
Comments: The enzyme found in bacteria accepts N-acetyl and N-glycoloyl derivatives [1].
Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 37318-35-7
References:
1. Ghosh, S. and Roseman, S. The sialic acids. IV. N-Acyl-D-glucosamine 6-phosphate 2-epimerase. J. Biol. Chem. 240 (1965) 1525-1530. [PMID: 14285487]
2. Manjunath, L., Guntupalli, S.R., Currie, M.J., North, R.A., Dobson, R.CJ., Nayak, V. and Subramanian, R. Crystal structures and kinetic analyses of N-acetylmannosamine-6-phosphate 2-epimerases from Fusobacterium nucleatum and Vibrio cholerae. Acta Crystallogr. F Struct. Biol. Commun. 74 (2018) 431–440. [PMID: 29969107]
3. Currie, M.J., Manjunath, L., Horne, C.R., Rendle, P.M., Subramanian, R., Friemann, R., Fairbanks, A.J., Muscroft-Taylor, A.C., North, R.A. and Dobson, R.CJ. N-acetylmannosamine-6-phosphate 2-epimerase uses a novel substrate-assisted mechanism to catalyze amino sugar epimerization. J. Biol. Chem. 297 (2021) 101113. [PMID: 34437902]