IUBMB Enzyme Nomenclature


Accepted name: ζ-carotene isomerase

Reaction: 9,15,9'-tricis-ζ-carotene = 9,9'-dicis-ζ-carotene

For diagram of reaction click here.

Other name(s): Z-ISO; 15-cis-ζ-carotene isomerase

Systematic name: 9,15,9'-tricis-ζ-carotene cis-trans-isomerase

Comments: The enzyme catalyses the cis-trans isomerization of the 15-15' carbon-carbon double bond in 9,15,9'-tricis-ζ-carotene, which is required for biosynthesis of all plant carotenoids. Requires heme b.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Chen, Y., Li, F. and Wurtzel, E.T. Isolation and characterization of the Z-ISO gene encoding a missing component of carotenoid biosynthesis in plants. Plant Physiol. 153 (2010) 66-79. [PMID: 20335404]

2. Li, F., Murillo, C. and Wurtzel, E.T. Maize Y9 encodes a product essential for 15-cis-ζ-carotene isomerization. Plant Physiol. 144 (2007) 1181-1189. [PMID: 17434985]

3. Beltran, J., Kloss, B., Hosler, J.P., Geng, J., Liu, A., Modi, A., Dawson, J.H., Sono, M., Shumskaya, M., Ampomah-Dwamena, C., Love, J.D. and Wurtzel, E.T. Control of carotenoid biosynthesis through a heme-based cis-trans isomerase. Nat. Chem. Biol. 11 (2015) 598–605. [PMID: 26075523]

[EC created 2011]

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