IUBMB Enzyme Nomenclature


Accepted name: prolycopene isomerase

Reaction: 7,9,7',9'-tetracis-lycopene = all-trans-lycopene

For diagram of reaction click here.

Glossary: prolycopene = 7,9,7',9'-tetracis-lycopene

Other name(s): CRTISO; carotene cis-trans isomerase; ZEBRA2 (gene name); carotene isomerase; carotenoid isomerase

Systematic name: 7,9,7',9'-tetracis-lycopene cis-trans-isomerase

Comments: Requires FADH2 [1]. The enzyme is involved in carotenoid biosynthesis.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Yu, Q., Ghisla, S., Hirschberg, J., Mann, V. and Beyer, P. Plant carotene cis-trans isomerase CRTISO: a new member of the FADred-dependent flavoproteins catalyzing non-redox reactions. J. Biol. Chem. 286 (2011) 8666-8676. [PMID: 21209101]

2. Li, Q., Farre, G., Naqvi, S., Breitenbach, J., Sanahuja, G., Bai, C., Sandmann, G., Capell, T., Christou, P. and Zhu, C. Cloning and functional characterization of the maize carotenoid isomerase and β-carotene hydroxylase genes and their regulation during endosperm maturation. Transgenic Res. 19 (2010) 1053-1068. [PMID: 20221689]

3. Isaacson, T., Ronen, G., Zamir, D. and Hirschberg, J. Cloning of tangerine from tomato reveals a carotenoid isomerase essential for the production of β-carotene and xanthophylls in plants. Plant Cell 14 (2002) 333-342. [PMID: 11884678]

4. Chai, C., Fang, J., Liu, Y., Tong, H., Gong, Y., Wang, Y., Liu, M., Wang, Y., Qian, Q., Cheng, Z. and Chu, C. ZEBRA2, encoding a carotenoid isomerase, is involved in photoprotection in rice. Plant Mol. Biol. 75 (2011) 211-221. [PMID: 21161331]

[EC created 2011]

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