IUBMB Enzyme Nomenclature


Accepted name: maleylacetoacetate isomerase

Reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate

For diagram of reaction click here.

Other name(s): maleylacetoacetic isomerase; maleylacetone isomerase; maleylacetone cis-trans-isomerase

Systematic name: 4-maleylacetoacetate cis-trans-isomerase

Comments: Also acts on maleylpyruvate.

Links to other databases: BRENDA, EAWAG-BBD, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9023-75-0


1. Edwards, S.W. and Knox, W.E. Homogentisate metabolism: the isomerization of methylacetoacetate by an enzyme which requires glutathione. J. Biol. Chem. 220 (1956) 79-91.

2. Lack, L. Enzymic cis-trans isomerization of maleylpyruvic acid. J. Biol. Chem. 236 (1961) 2835-2840.

3. Seltzer, S. Purification and properties of maleylacetone cis-trans isomerase from Vibrio 01. J. Biol. Chem. 248 (1973) 215-222. [PMID: 4692831]

[EC created 1961]

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