Reaction: 3-maleylpyruvate = 3-fumarylpyruvate
Other name(s): nagL (gene name); ncgl2918 (gene name); PA2437 (gene name)
Systematic name: 3-maleylpyruvate cis-trans-isomerase
Comments: The enzyme participates in a gentisate degradation pathway. Characterized enzymes require a thiol cofactor, though enzymes from different organisms utilize different thiols (e.g. glutathione, mycothiol, and L-cysteine).
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9023-77-2
References:
1. Lack, L. Enzymic cis-trans isomerization of maleylpyruvic acid. J. Biol. Chem. 236 (1961) 2835-2840. [PMID: 14461395]
2. Zhou, N.Y., Fuenmayor, S.L. and Williams, P.A. nag genes of Ralstonia (formerly Pseudomonas) sp. strain U2 encoding enzymes for gentisate catabolism. J. Bacteriol. 183 (2001) 700-708. [PMID: 11133965]
3. Feng, J., Che, Y., Milse, J., Yin, Y.J., Liu, L., Ruckert, C., Shen, X.H., Qi, S.W., Kalinowski, J. and Liu, S.J. The gene ncgl2918 encodes a novel maleylpyruvate isomerase that needs mycothiol as cofactor and links mycothiol biosynthesis and gentisate assimilation in Corynebacterium glutamicum. J. Biol. Chem. 281 (2006) 10778-10785. [PMID: 16481315]
4. Hong, H., Seo, H. and Kim, K.J. Structure and biochemical studies of a pseudomonad maleylpyruvate isomerase from Pseudomonas aeruginosa PAO1. Biochem. Biophys. Res. Commun. 514 (2019) 991-997. [PMID: 31092332]