IUBMB Enzyme Nomenclature


Accepted name: corticosteroid side-chain-isomerase

Reaction: 11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al

Other Name(s): 11-deoxycorticosterone ketol-isomerase

Systematic name: 11-deoxycorticosterone aldose-ketose-isomerase

Comments: An epimerization at C-20 and C-21 is probably catalysed by the same enzyme.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 75139-73-0


1. Martin, K.O., Oh, S.-W., Lee, H.J. and Monder, C. Studies on 21-3H-labeled corticosteroids: evidence for isomerization of the ketol side chain of 11-deoxycorticosterone by a hamster liver enzyme. Biochemistry 16 (1977) 3803-3809. [PMID: 901753]

2. Monder, C., Martin, K.O. and Bogumil, J. Presence of epimerase activity in hamster liver corticosteroid side chain isomerase. J. Biol. Chem. 255 (1980) 7192-7198. [PMID: 7391077]

[EC created 1983]

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