IUBMB Enzyme Nomenclature


Accepted name: ribose-1,5-bisphosphate isomerase

Reaction: α-D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate

For diagram of reaction click here.

Other name(s): R15P isomerase; ribulose 1,5-bisphosphate synthase; RuBP synthase

Systematic name: α-D-ribose 1,5-bisphosphate aldose-ketose-isomerase

Comments: This archaeal enzyme is involved in AMP metabolism and CO2 fixation through type III RubisCO enzymes. The enzyme is activated by cAMP [2].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Sato, T., Atomi, H. and Imanaka, T. Archaeal type III RuBisCOs function in a pathway for AMP metabolism. Science 315 (2007) 1003-1006. [PMID: 17303759]

2. Aono, R., Sato, T., Yano, A., Yoshida, S., Nishitani, Y., Miki, K., Imanaka, T. and Atomi, H. Enzymatic characterization of AMP phosphorylase and ribose-1,5-bisphosphate isomerase functioning in an archaeal AMP metabolic pathway. J. Bacteriol. 194 (2012) 6847-6855. [PMID: 23065974]

3. Nakamura, A., Fujihashi, M., Aono, R., Sato, T., Nishiba, Y., Yoshida, S., Yano, A., Atomi, H., Imanaka, T. and Miki, K. Dynamic, ligand-dependent conformational change triggers reaction of ribose-1,5-bisphosphate isomerase from Thermococcus kodakarensis KOD1. J. Biol. Chem. 287 (2012) 20784-20796. [PMID: 22511789]

[EC created 2013]

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