IUBMB Enzyme Nomenclature


Accepted name: (4S)-4-hydroxy-5-phosphooxypentane-2,3-dione isomerase

Reaction: (4S)-4-hydroxy-5-phosphooxypentane-2,3-dione = 3-hydroxy-5-phosphooxypentane-2,4-dione

Glossary: (4S)-4,5-dihydroxypentane-2,3-dione = autoinducer 2 = AI-2

Other name(s): lsrG (gene name); phospho-AI-2 isomerase; (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase; (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione aldose-ketose-isomerase

Systematic name: (4S)-4-hydroxy-5-phosphooxypentane-2,3-dione aldose-ketose-isomerase

Comments: The enzyme participates in a degradation pathway of the bacterial quorum-sensing autoinducer molecule AI-2.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number:


1. Xavier, K.B., Miller, S.T., Lu, W., Kim, J.H., Rabinowitz, J., Pelczer, I., Semmelhack, M.F. and Bassler, B.L. Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria. ACS Chem. Biol. 2 (2007) 128-136. [PMID: 17274596]

2. Marques, J.C., Lamosa, P., Russell, C., Ventura, R., Maycock, C., Semmelhack, M.F., Miller, S.T. and Xavier, K.B. Processing the interspecies quorum-sensing signal autoinducer-2 (AI-2): characterization of phospho-(S)-4,5-dihydroxy-2,3-pentanedione isomerization by LsrG protein. J. Biol. Chem. 286 (2011) 18331-18343. [PMID: 21454635]

[EC created 2015]

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