IUBMB Enzyme Nomenclature


Accepted name: glucose-6-phosphate isomerase

Reaction: α-D-glucose 6-phosphate = β-D-fructofuranose 6-phosphate

For diagram of reaction click here, another example click here, another example click here another example click here

Other name(s): phosphohexose isomerase; phosphohexomutase; oxoisomerase; hexosephosphate isomerase; phosphosaccharomutase; phosphoglucoisomerase; phosphohexoisomerase; phosphoglucose isomerase; glucose phosphate isomerase; hexose phosphate isomerase; D-glucose-6-phosphate ketol-isomerase

Systematic name: α-D-glucose-6-phosphate aldose-ketose-isomerase (configuration-inverting)

Comments: The enzyme from yeast catalyses the reversible conversion specifically between the α-D-glucose 6-phosphate and β-D-fructofuranose 6-phosphate. The enzyme also catalyses the anomerization of both D-hexose 6-phosphates [7].

Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9001-41-6


1. Ramasarma, T. and Giri, K.V. Phosphoglucose isomerase of green gram (Phaseolus radiatus). Arch. Biochem. Biophys. 62 (1956) 91-96. [PMID: 13314642]

2. Tsuboi, K.K., Estrada, J. and Hudson, P.B. Enzymes of the human erythrocytes. IV. Phosphoglucose isomerase, purification and properties. J. Biol. Chem. 231 (1958) 19-29. [PMID: 13538944]

3. Noltmann, E. and Bruns, F.H. Reindarstellung und Eigenschaften von Phosphoglucose-isomerase aus Hefe. Biochem. Z. 331 (1959) 436-445.

4. Baich, A., Wolfe, R.G. and Reithel, F.J. The enzymes of mammary gland. I. Isolation of phosphoglucose isomerase. J. Biol. Chem. 235 (1960) 3130-3133. [PMID: 13685918]

5. Noltmann, E.A. Isolation of crystalline phosphoglucose isomerase from rabbit muscle. J. Biol. Chem. 239 (1964) 1545-1550. [PMID: 14189891]

6. Nakagawa, Y. and Noltmann, E.A. Isolation of crystalline phosphoglucose isomerase from brewers' yeast. J. Biol. Chem. 240 (1965) 1877-1881. [PMID: 14299604]

7. Willem, R., Biesemans, M., Hallenga, K., Lippens, G., Malaisse-Lagae, F. and Malaisse, W.J. Dual anomeric specificity and dual anomerase activity of phosphoglucoisomerase quantified by two-dimensional phase-sensitive 13C EXSY NMR. J. Biol. Chem. 267 (1992) 210-217. [PMID: 1730590]

[EC created 1961, modified 1976 (EC created part 1972, incorporated 1978), modified 2021]

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