IUBMB Enzyme Nomenclature


Accepted name: phosphoenolpyruvate mutase

Reaction: phosphoenolpyruvate = 3-phosphonopyruvate

For diagram of reaction click here.

Other name(s): phosphoenolpyruvate-phosphonopyruvate phosphomutase; PEP phosphomutase; phosphoenolpyruvate phosphomutase; PEPPM

Systematic name: phosphoenolpyruvate 2,3-phosphonomutase

Comments: Involved in the biosynthesis of the C-P bond, although the equilibrium greatly favours phosphoenolpyruvate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 115756-49-5


1. Bowman, E., McQueney, M., Barry, R.J. and Dunaway-Mariano, D. Catalysis and thermodynamics of the phosphoenolpyruvate phosphonopyruvate rearrangement - entry into the phosphonate class of naturally-occurring organo-phosphorus compounds. J. Am. Chem. Soc. 110 (1988) 5575-5576.

2. Hikada, T., Imai, S., Hara, O., Anzai, H., Murakami, T., Nagaoka, K. and Seto, H. Carboxyphosphonoenolpyruvate phosphonomutase, a novel enzyme catalyzing C-P bond formation. J. Bacteriol. 172 (1990) 3066-3072. [PMID: 2160937]

3. Seidel, H.M., Freeman, S. and Knowles, J.R. Phosphonate biosynthesis: isolation of the enzyme responsible for the formation of a carbon-phosphorus bond. Nature 335 (1988) 457-458. [PMID: 3138545]

[EC created 1990]

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