IUBMB Enzyme Nomenclature


Accepted name: 2-methyleneglutarate mutase

Reaction: 2-methyleneglutarate = 2-methylene-3-methylsuccinate

For diagram click here.

Other name(s): α-methyleneglutarate mutase

Systematic name: 2-methyleneglutarate carboxy-methylenemethylmutase

Comments: Requires a cobamide coenzyme.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, CAS registry number: 9059-10-3


1. Kung, H.-F., Cederbaum, S., Tsai, L. and Stadtman, T.C. Nicotinic acid metabolism. V. A cobamide coenzyme-dependent conversion of α-methyleneglutaric acid to dimethylmaleic acid. Proc. Natl. Acad. Sci. USA 65 (1970) 978-984. [PMID: 5266166]

2. Kung, H.-F. and Stadtman, T.C. Nicotinic acid metabolism. VI. Purification and properties of α-methyleneglutarate mutase (B12-dependent) and methylitaconate isomerase. J. Biol. Chem. 246 (1971) 3378-3388. [PMID: 5574401]

[EC created 1972]

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