IUBMB Enzyme Nomenclature

EC 5.4.99.52

Accepted name: α-seco-amyrin synthase

Reaction: (3S)-2,3-epoxy-2,3-dihydrosqualene = α-seco-amyrin

For diagram of reaction click here.

Glossary: α-seco-amyrin = 8,14-secoursa-7,13-diene-3β-ol

Systematic name: (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, α-seco-amyrin-forming)

Comments: The enzyme from Arabidopsis thaliana is multifunctional and produces about equal amounts of α- and β-seco-amyrin. See EC 5.4.99.54, β-seco-amyrin synthase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Shibuya, M., Xiang, T., Katsube, Y., Otsuka, M., Zhang, H. and Ebizuka, Y. Origin of structural diversity in natural triterpenes: direct synthesis of seco-triterpene skeletons by oxidosqualene cyclase. J. Am. Chem. Soc. 129 (2007) 1450-1455. [PMID: 17263431]

[EC 5.4.99.52 created 2011]


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