IUBMB Enzyme Nomenclature


Accepted name: cobalt-precorrin-8 methylmutase

Reaction: cobalt-precorrin-8 = cobyrinate

For diagram of reaction click here.

Other name(s): cbiC (gene name)

Systematic name: precorrin-8 11,12-methylmutase

Comments: The enzyme, which participates in the anaerobic (early cobalt insertion) adenosylcobalamin biosynthesis pathway, catalyses the conversion of cobalt-precorrin-8 to cobyrinate by methyl rearrangement. The equivalent enzyme in the aerobic pathway is EC, precorrin-8X methylmutase.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number:


1. Xue, Y., Wei, Z., Li, X. and Gong, W. The crystal structure of putative precorrin isomerase CbiC in cobalamin biosynthesis. J. Struct. Biol. 153 (2006) 307-311. [PMID: 16427313]

2. Moore, S.J., Lawrence, A.D., Biedendieck, R., Deery, E., Frank, S., Howard, M.J., Rigby, S.E. and Warren, M.J. Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12). Proc. Natl. Acad. Sci. USA 110 (2013) 14906-14911. [PMID: 23922391]

[EC created 2014]

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