IUBMB Enzyme Nomenclature


Accepted name: ethylmalonyl-CoA mutase

Reaction: (2R)-ethylmalonyl-CoA = (2S)-methylsuccinyl-CoA

Other name(s): Ecm

Systematic name: (2R)-ethylmalonyl-CoA CoA-carbonylmutase

Comments: The enzyme, characterized from the bacterium Rhodobacter sphaeroides, is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation. Requires coenzyme B12 for activity.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Erb, T.J., Retey, J., Fuchs, G. and Alber, B.E. Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases. J. Biol. Chem. 283 (2008) 32283-32293. [PMID: 18819910]

[EC created 2015]

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