IUBMB Enzyme Nomenclature


Accepted name: dichloromuconate cycloisomerase

Reaction: 2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate = 2,4-dichloro-cis,cis-muconate

For diagram click here.

Other name(s): α-pinene oxide lyase; α-pinene-oxide lyase (decyclizing)

Systematic name: α-pinene-oxide lyase (ring-opening)

Comments: Requires Mn2+. The product of cycloisomerization of dichloro-cis,cis-muconate spontaneously eliminates chloride to produce cis-4-carboxymethylene-3-chlorobut-2-en-4-olide. Also acts, in the reverse direction, on cis,cis-muconate and its monochloro-derivatives, but with lower affinity. Not identical with EC (muconate cycloisomerase) or EC (chloromuconate cycloisomerase).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, UM-BBD, CAS registry number: 126904-95-8


1. Kuhm, A.E., Schlömann, M., Knackmuss, H.-J. and Pieper, D.H. Purification and characterization of dichloromuconate cycloisomerase from Alcaligenes eutrophus JMP 134. Biochem. J. 266 (1990) 877-883. [PMID: 2327971]

[EC created 1992]

Return to EC 5.5.1 home page
Return to EC 5.5 home page
Return to EC 5 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page